Avcc 140202
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چکیده
1 ©2003 International Medical Press 0956-3202/02/$17.00 Influenza continues to be a major cause of high morbidity and significant mortality both in humans and domestic animals. Despite the success in development of anti-influenza drugs (Colacino et al., 2000), a need continues to exist for effective therapies for influenza virus infection. The extracts and products of plant origin provide an alternative source for substances with virus-inhibitory activities (for review see Che, 2001; Vanden Berghe et al., 1986). Thalictrum species (Ranunculaceae) are notable for their rich alkaloid content. Though some biological and pharmacological properties have been reported (Mitscher et al., 1972; Wu et al., 1977), their antiviral activities have been investigated insufficiently. In a screening study we examined the anti-influenza virus effects of some isoquinoline alkaloids from Thalictrum species (Serkedjieva & Velcheva, 2003), (+)-thalfoetidine from T. flavum, hernandezine and protopine from T. foetidum, (–)-thalimonine, (–)-thalimonin N-oxide, thalictuberine N-oxide from T. simplex as well as two synthetic analogues of Thl (Pabuccouglu & Hesse, 1997). (–)-Thalimonine (3,4-methylene-deoxy2,8,9-trimethoxypavinan, Figure 1) and its N-oxide inhibited significantly viral reproduction; thalictuberine N-oxide was less active. The rest of the tested alkaloids did not show any virus-inhibitory activity, applied in non-cytotoxic concentrations. The present study focuses on the virusinhibitory effect of Thl. Materials and methods
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تاریخ انتشار 2003